A Case of pediatric virilizing adrenocortical tumor resulting in hypothalamic-pituitary activation and central precocious puberty following surgical removal

Yoko Miyoshi, Takaharu Oue, Mitsugu Oowari, Hideki Soh, Makiko Tachibana, Sadami Kimura, Yuki Kiyohara, Hiroyuki Yamada, Kazuhiko Bessyo, Sotaro Mushiake, Keiko Homma, Tomonobu Hasegawa, Hironobu Sasano, Keiichi Ozono

研究成果: Article査読

4 被引用数 (Scopus)

抄録

We present a 6-year-old boy with a virilizing adrenocortical tumor who initially presented with peripheral precocious puberty. Development of facial acne, pubic hair and a growth spurt were noted at the age of five. A low-pitched voice as well as maturation of external genitalia was noted at the age of six, Both serum and urinary levels of adrenal androgens were elevated. Abdominal computed tomography revealed a large right suprarenal mass and he underwent surgical resection without any complications. The histological diagnosis was adrenocortical carcinoma according to the criteria of Weiss. Following surgical removal of the androgen-producing tumor, the patient subsequently developed hypothalamic-pituitary activation and demonstrated central precocious puberty. He was treated with a gonadotropin-releasing hormone agonist in order to delay further pubertal progression. Clinical follow-up of potential secondary effects of excess hormone secretion after removal is important in some pediatric patients with virilizing adrenocortical tumor,.

本文言語English
ページ(範囲)975-982
ページ数8
ジャーナルEndocrine journal
56
8
DOI
出版ステータスPublished - 2009

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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