A case of rheumatoid arthritis complicated with salazosulfapyridine-induced aplastic anemia

Akira Suwa, Shinichi Inada, Shinichi Kawai, Michito Hirakata, Arikuni Nakamura

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A 64 year-old woman with rheumatoid arthritis was admitted to our hospital because of general fatigue. She noticed polyarthralgia 8 months prior to the admission and diagnosis of rheumatoid arthritis was made. Administration of salazosulfapyridine (1.0g/day) was started 6 months before the admission. Complete remission of rheumatoid arthritis was obtained in 2 months and blood cell counts showed normal values at that time. The results of laboratory tests included hemoglobin; 8.6 g/dl, white blood cell count; 1, 900/mm3 with a differential of 19% neutrophils, 77% lymphocytes, and 4% moeocytes; platelets were 21, 000/mm3. A bone marrow aspiration and biopsy were performed. There were reduced numbers of myelocytes, erythroblasts, and megakaryocytes indicating aplastic anemia. Salazosulfapyridine was discontinued. Prednisolone, anabolic steroid and granulocyte-colony stimulating factor (G-CSF) were administrated. In spite of these therapy, recovery of peripheral blood cell counts have not been observed and supporting therapy including red cell and platelets transfusion have been continued. To our knowledge, this is the first case report which describes occurrence of aplastic anemia in patients with rheumatoid arthritistreated by salazosulfapyridine.

本文言語English
ページ(範囲)116-122
ページ数7
ジャーナルJapanese Journal of Clinical Immunology
18
1
DOI
出版ステータスPublished - 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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