A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole

Hitoshi Ichikawa, Hirotoshi Ebinuma, Shinichirou Tada, Keisuke Ojiro, Yoshiyuki Yamagishi, Nobuhiro Tsukada, Emi Hongou, Osamu Funae, Rie Irie, Hidetsugu Saito, Toshifumi Hibi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Liver dysfunction is a common complication observed in patients with hyperthyroidism, however the dysfunction is always mild and obvious jaundice is rarely observed. We present the case of a 43-year-old man who suffered from hyperthyroidism complicated by severe jaundice. The jaundice likely occurred as a secondary consequence of cholestasis due to hyperthyroidism, since other causes such as drug-induced or autoimmune liver dysfunction were ruled out. Treatment with methimazole improved severe cholestatic jaundice in parallel with normalization of thyroid function. The mechanism of cholestasis as a secondary complication of hyperthyroidism has not been uncovered and there is no specific biochemical marker for cholestasis due to this hormonal disease at present. This case serves as a reminder that severe jaundice can be a manifestation of simple hyperthyroidism, and that administration of antithyroid drugs is an effective treatment for severe cholestatic jaundice in such cases.

本文言語English
ページ(範囲)315-319
ページ数5
ジャーナルClinical journal of gastroenterology
2
4
DOI
出版ステータスPublished - 2009 8 1

ASJC Scopus subject areas

  • Gastroenterology

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