TY - JOUR
T1 - A case of spinal and bulbar muscular atrophy with high-stage and high-gleason score prostate cancer responded to maximal androgen blockade therapy
AU - Kosaka, Takeo
AU - Miyajima, Akira
AU - Kikuchi, Eiji
AU - Takahashi, Shinichi
AU - Suzuki, Norihiro
AU - Oya, Mototsugu
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by the expansion of CAG triplets in the androgen receptor. Because the length of CAG repeat is inversely related with androgen receptor function, patients with a longer CAG repeat are expected to have a lower incidence of prostate cancer. Here, we report an extremely rare case of highstage prostate cancer in a patient with spinal and bulbar muscular atrophy, which responded to maximal androgen blockade therapy.
AB - Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by the expansion of CAG triplets in the androgen receptor. Because the length of CAG repeat is inversely related with androgen receptor function, patients with a longer CAG repeat are expected to have a lower incidence of prostate cancer. Here, we report an extremely rare case of highstage prostate cancer in a patient with spinal and bulbar muscular atrophy, which responded to maximal androgen blockade therapy.
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U2 - 10.2164/jandrol.111.013698
DO - 10.2164/jandrol.111.013698
M3 - Article
C2 - 21940987
AN - SCOPUS:84866412204
VL - 33
SP - 563
EP - 565
JO - Journal of Andrology
JF - Journal of Andrology
SN - 0196-3635
IS - 4
ER -