A Clinic-based Survey of Clinical Characteristics and Practice Pattern of Dry Eye in Japan

The DECS-J Study Group

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Introduction: The aim of this study was to investigate the clinical characteristics and practice pattern of patients with dry eye disease (DED) in eye clinics across Japan. Methods: A multi-center, cross-sectional study was conducted among patients with DED who visited eye clinics in Japan. Subjective symptoms, patient’s background, ocular surface features, and tear function were evaluated. Main outcome measures were tear break-up time (TBUT), Schirmer I value, kerato-conjunctival staining score, and dry eye symptom questionnaire score. Results: Initially, 463 subjects were enrolled, and 449 cases (63 male and 386 female; mean age, 62.6 ± 15.7 years) were included in the final analysis. Overall, 94.9% of patients had a shortened TBUT (≤5 s), and 54.6% had an aqueous tear deficiency (Schirmer I value ≤5 mm). The most prevalent subtype of dry eye was aqueous-deficient dry eye, which was present in 35.0% of all patients, followed by short-BUT-type dry eye, which was seen in 26.7%. Conclusion: The two most common DED subtypes were aqueous-deficient and short-BUT-type dry eye. Shortened TBUT is the most common feature of dry eye, regardless of subtype. The current treatment choice mainly consisted of hyaluronic acid, two novel mucin secretagogues, diquafosol and rebamipide, and steroidal eye drops. Trial Registration: University Hospital Medical Information Network: UMIN (registries no. UMIN 000015890). Funding: Japan Dry Eye Society, Tokyo, Japan, and Santen Pharmaceutical Co., Ltd., Osaka, Japan.

本文言語English
ページ(範囲)732-743
ページ数12
ジャーナルAdvances in Therapy
34
3
DOI
出版ステータスPublished - 2017 3月 1

ASJC Scopus subject areas

  • 薬理学(医学)

フィンガープリント

「A Clinic-based Survey of Clinical Characteristics and Practice Pattern of Dry Eye in Japan」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル