A combination of serum anti-Helicobacter pylori antibody titer and Kyoto classification score could provide a more accurate diagnosis of H pylori

Toshihiro Nishizawa, Kosuke Sakitani, Hidekazu Suzuki, Tadahiro Yamakawa, Yoshiyuki Takahashi, Nobutake Yamamichi, Hidenobu Watanabe, Yasuyuki Seto, Kazuhiko Koike, Osamu Toyoshima

研究成果: Article

3 引用 (Scopus)

抜粋

Background: We previously showed that the endoscopic Kyoto classification for gastritis could predict Helicobacter pylori infection in individuals with a high negative titer of serum anti-H pylori antibodies. This study evaluated H pylori infection and the Kyoto classification score in patients with a low negative titer (<3 U/ml), high negative titer (3–9.9 U/ml), low positive titer (10–49.9 U/ml), and high positive titer (≥50 U/ml). Methods: Serum antibody levels, Kyoto classification score and histology were investigated in 870 individuals with no history of H pylori-eradication therapy. Urea breath tests (UBTs) were additionally conducted for patients with a low negative titer and a Kyoto score ≥1 or an antibody titer ≥10 U/ml and a Kyoto score of 0 or 1. UBTs and/or histological studies were conducted for participants with a high negative titer. Results: False diagnoses based on anti-H pylori antibody titers were observed in 0.3% of the low-negative-titer group, 11.7% of the high-negative-titer group, 18.9% of the low-positive-titer group and 2.2% of the high-positive-titer group. Surprisingly, false diagnoses based on antibody titers were noted in 63.2% of patients with a low positive titer and a Kyoto score of 0 and in 62.5% of patients with a high negative titer and a Kyoto score ≥2, respectively. Conclusions: Endoscopic findings could predict false diagnoses determined using serum antibody titers.

元の言語English
ページ(範囲)343-348
ページ数6
ジャーナルUnited European Gastroenterology Journal
7
発行部数3
DOI
出版物ステータスPublished - 2019 4 1

    フィンガープリント

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

これを引用

Nishizawa, T., Sakitani, K., Suzuki, H., Yamakawa, T., Takahashi, Y., Yamamichi, N., Watanabe, H., Seto, Y., Koike, K., & Toyoshima, O. (2019). A combination of serum anti-Helicobacter pylori antibody titer and Kyoto classification score could provide a more accurate diagnosis of H pylori. United European Gastroenterology Journal, 7(3), 343-348. https://doi.org/10.1177/2050640619825947