A comparison of the abdominal fat distribution and coronary risk markers in body mass index-matched subjects with and without fatty liver

Yutaka Shiina, Koichiro Homma, Hideki Ozawa, Joe Yoshizawa, Takako Kobayashi, Mihoko Igarashi, Minoru Aikawa, Takeo Shibata, Yasuhiko Homma

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Objective The close relationship between fatty liver and metabolic syndrome suggests that individuals with fatty liver may have multiple coronary risk factors. In the present study, we investigated the relationships among fatty liver, abdominal fat distribution, and coronary risk markers. Methods and Results Eighty-seven pairs of men and 42 pairs of women who were matched for age and body mass index were enrolled in the present study. The obesity-related markers, abdominal fat distribution (examined by CT), and coronary risk markers were compared in subjects with and without fatty liver. The visceral fat area was significantly larger in the men with fatty liver than in the men without fatty liver. The plasma levels of triglyceride and low-density lipoprotein cholesterol (LDL-C), as well as the homeostasis model assessment-insulin resistance level, were higher in both males and females with fatty liver than in those without fatty liver, while the plasma levels of high-density lipoprotein cholesterol (HDL-C) and adiponectin were lower in the males and females with fatty liver. The plasma levels of apolipoprotein B, remnant-like particle cholesterol (RLP-C), and oxidized LDL were higher in men with fatty liver, but not in women with fatty liver. Conclusion Both males and females with fatty liver had lower insulin sensitivity, lower plasma levels of HDL-C and adiponectin, and higher triglyceride and LDL-C levels. However, the plasma levels of apolipoprotein B, RLP-C, and oxidized LDL were only higher and closely associated with fatty liver in men. Men with fatty liver had a higher risk of coronary disease than women with fatty liver.

本文言語English
ページ(範囲)2549-2554
ページ数6
ジャーナルInternal Medicine
55
18
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • Internal Medicine

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