A Concise Total Synthesis of Dehydroantofine and Its Antimalarial Activity against Chloroquine-Resistant Plasmodium falciparum

Naoto Yamasaki, Ikumi Iwasaki, Kazu Sakumi, Rei Hokari, Aki Ishiyama, Masato Iwatsuki, Masataka Nakahara, Shuhei Higashibayashi, Takeshi Sugai, Hiroshi Imagawa, Miwa Kubo, Yoshiyasu Fukuyama, Satoshi Ōmura, Hirofumi Yamamoto

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The total synthesis of dehydroantofine was achieved by employing a novel, regioselective, azahetero Diels–Alder reaction of easily accessible 3,5-dichloro-2H-1,4-oxazin-2-one with 14 a as a key step. Furthermore, it is demonstrated that dehydroantofine is a promising candidate as a new antimalarial agent in a biological assay with chloroquine-resistant Plasmodium falciparum.

本文言語English
ページ(範囲)5555-5563
ページ数9
ジャーナルChemistry - A European Journal
27
17
DOI
出版ステータスPublished - 2021 3 22

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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