A critical mutation in both WT1 alleles is not sufficient to cause Wilms' tumor

Haruhito Kikuchi, Yoshikiyo Akasaka, Yoshihiro Kurosawa, Hiroshi Yoneyama, Shingo Kato, Jun ichi Hata

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The WT1 gene is a tumor suppresser gene for Wilms' tumor (WT). Inactivation of both alleles has been proposed as the cause of WT. We encountered a patient with Denys-Drash syndrome associated with WT whose WT1 gene had a homozygous point mutation not only in WT but also in renal tissue adjacent to the WT and in the germline. These findings indicate that factor(s) other than the loss of WT1 are required for WT to develop.

本文言語English
ページ(範囲)26-28
ページ数3
ジャーナルFEBS Letters
360
1
DOI
出版ステータスPublished - 1995 2月 20
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

フィンガープリント

「A critical mutation in both WT1 alleles is not sufficient to cause Wilms' tumor」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル