A cross-sectional exploratory survey on occurrence of triple-whammy prescription pattern in Japan

Shungo Imai, Kenji Momo, Hitoshi Kashiwagi, Takayuki Miyai, Mitsuru Sugawara, Yoh Takekuma

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Background The concurrent use of nonsteroidal anti-inflammatory drugs, renin–angiotensin–aldosterone system blockers, and diuretics, known as a “triple-whammy,” is related to the occurrence of acute kidney injury. However, there are few reports regarding the prescription pattern of the triple-whammy. Objective To elucidate the patterns of the triple-whammy prescription in Japan. Methods A cross-sectional study was performed using a health-insurance-claims database that included Japanese people under 75 years of age, and enrolled outpatients that were prescribed any nonsteroidal anti-inflammatory drugs, renin–angiotensin–aldosterone system blockers, and diuretics between April 2017 and June 2017. As an outcome, the proportion of triple-whammy prescriptions was evaluated. Among the patients who received triple-whammy prescriptions, we evaluated the prevalence of chronic kidney disease and the proportion of prescriptions provided for these three drugs from different clinical departments and institutions. Results Overall, 730 of 246,721 (0.3%) patients received triple-whammy prescriptions. Among these patients, 13.3% had underlying chronic kidney disease. The proportions of any of the three drug types prescribed by different clinical departments and institutions was 48.2% and 61.8%, respectively. Conclusions We examined the patterns of triple-whammy prescriptions and concluded that pharmacists need to pay attention to triple-whammy prescriptions if the prescriptions are provided by multiple clinical departments or institutions.

本文言語English
ページ(範囲)1369-1373
ページ数5
ジャーナルInternational Journal of Clinical Pharmacy
42
5
DOI
出版ステータスPublished - 2020 10月 1
外部発表はい

ASJC Scopus subject areas

  • 薬学
  • 毒物学
  • 薬理学
  • 薬科学
  • 薬理学(医学)

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