A designed amide as an aldol donor in the direct catalytic asymmetric aldol reaction

Karin Weidner, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

48 被引用数 (Scopus)

抄録

The direct catalytic asymmetric aldol reaction offers efficient access to β-hydroxy carbonyl entities. Described is a robust direct catalytic asymmetric aldol reaction of α-sulfanyl 7-azaindolinylamide, thus affording both aromatic and aliphatic β-hydroxy amides with high ee values. The design of this transformation features a cooperative interplay of a soft and a hard Lewis acid, which together facilitate the challenging chemoselective enolization by a hard Brønsted base.

本文言語English
ページ(範囲)6150-6154
ページ数5
ジャーナルAngewandte Chemie - International Edition
53
24
DOI
出版ステータスPublished - 2014 6月 10
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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