A direct catalytic asymmetric aldol reaction of α-sulfanyl lactones: Efficient synthesis of SPT inhibitors

Sho Takechi, Shigeo Yasuda, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Softly does it: The title reaction, catalyzed by a AgPF 6/(R)- biphep-type ligand/DBU complex, is described (see scheme). This protocol gives efficient access to syn-configured α-sulfanyl-β-hydroxy lactones in a highly enantioselective manner. In one particular case, the sulfide group was stereospecifically replaced with a hydroxy group to afford an enantioenriched tertiary alcohol, which upon further manipulation led to a class of densely functionalized SPT inhibitors.

本文言語English
ページ(範囲)4218-4222
ページ数5
ジャーナルAngewandte Chemie - International Edition
51
17
DOI
出版ステータスPublished - 2012 4 23
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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