A direct entry to substituted n-methoxyamines from n-methoxyamides via n-oxyiminium ions

Kenji Shirokane; Kurosaki Yusuke; Takaaki Sato; Noritaka Chida

doi:10.1002/anie.201001127

A direct entry to substituted n-methoxyamines from n-methoxyamides via n-oxyiminium ions

Kenji Shirokane, Kurosaki Yusuke, Takaaki Sato, Noritaka Chida

応用化学科

研究成果: Article › 査読

94 被引用数 (Scopus)

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Take the direct path: Sequential nucleophilic addition of N-methoxyamides using DIBAL and organometallic reagents provided substituted N-methoxyamines in one pot via five-membered chelated intermediates (see scheme, DIBAL=diisobutylaluminum hydride). The reaction allows functionalization of acyclic amides and macrolactams without a preactivation step, which is generally required for inert amide carbonyl groups.

本文言語	English
ページ（範囲）	6369-6372
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	49
号	36
DOI	https://doi.org/10.1002/anie.201001127
出版ステータス	Published - 2010 8月 23

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化学 (全般)

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10.1002/anie.201001127

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AU - Chida, Noritaka

PY - 2010/8/23

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KW - Cyclization

KW - Macrocycles

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A direct entry to substituted n-methoxyamines from n-methoxyamides via n-oxyiminium ions

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