A direct role for Hsp90 in pre-RISC formation in Drosophila

Tomohiro Miyoshi, Akiko Takeuchi, Haruhiko Siomi, Mikiko C. Siomi

研究成果: Article

102 引用 (Scopus)

抜粋

Heat-shock proteins (Hsps) are molecular chaperones that control protein folding and function. Argonaute 2 (Ago2), the effector in RNA interference (RNAi), is associated with Hsp90; however, its function in RNAi remains elusive. Here we show that Hsp90 is required for Ago2 to receive the small interfering RNA (siRNA) duplex from the RNA-induced silencing complexĝ€" loading complex in RNAi, suggesting a model where Hsp90 modifies Ago2 conformation to accommodate the siRNA duplex.

元の言語English
ページ(範囲)1024-1026
ページ数3
ジャーナルNature Structural and Molecular Biology
17
発行部数8
DOI
出版物ステータスPublished - 2010 8 1

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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