A general computational model of mitochondrial metabolism in a whole organelle scale

Katsuyuki Yugi, Masaru Tomita

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Summary: A computational tool for mitochondrial systems biology has been developed as a simulation model of E-Cell2, a publicly available simulation system. The general model consists of 58 enzymatic reactions and 117 metabolites, representing the respiratory chain, the TCA cycle, the fatty acid β-oxidation and the inner-membrane transport system. It is based on previously published enzyme kinetics studies in the literature; we have successfully integrated and packaged them into a single large model. The model can be easily extended and modified so that mitochondrial biologists/physiologists can integrate their own models and evaluate them in the context of the whole organelle metabolism.

本文言語English
ページ(範囲)1795-1796
ページ数2
ジャーナルBioinformatics
20
11
DOI
出版ステータスPublished - 2004 7月 22

ASJC Scopus subject areas

  • 統計学および確率
  • 生化学
  • 分子生物学
  • コンピュータ サイエンスの応用
  • 計算理論と計算数学
  • 計算数学

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