A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis

Yohei Takahashi, Ikuyo Kou, Atsushi Takahashi, Todd A. Johnson, Katsuki Kono, Noriaki Kawakami, Koki Uno, Manabu Ito, Shohei Minami, Haruhisa Yanagida, Hiroshi Taneichi, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Toshiaki Kotani, Kota Watanabe, Kazuhiro Chiba, Naoya Hosono, Naoyuki Kamatani, Tatsuhiko TsunodaYoshiaki Toyama, Michiaki Kubo, Morio Matsumoto, Shiro Ikegawa

研究成果: Article

133 引用 (Scopus)

抜粋

Adolescent idiopathic scoliosis is a pediatric spinal deformity affecting 2-3% of school-age children worldwide. Genetic factors have been implicated in its etiology. Through a genome-wide association study (GWAS) and replication study involving a total of 1,376 Japanese females with adolescent idiopathic scoliosis and 11,297 female controls, we identified a locus at chromosome 10q24.31 associated with adolescent idiopathic scoliosis susceptibility. The most significant SNP (rs11190870; combined P = 1.24 × 10 -19; odds ratio (OR) = 1.56) is located near LBX1 (encoding ladybird homeobox 1). The identification of this susceptibility locus provides new insights into the pathogenesis of adolescent idiopathic scoliosis.

元の言語English
ページ(範囲)1237-1240
ページ数4
ジャーナルNature genetics
43
発行部数12
DOI
出版物ステータスPublished - 2011 12

ASJC Scopus subject areas

  • Genetics

フィンガープリント A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Takahashi, Y., Kou, I., Takahashi, A., Johnson, T. A., Kono, K., Kawakami, N., Uno, K., Ito, M., Minami, S., Yanagida, H., Taneichi, H., Tsuji, T., Suzuki, T., Sudo, H., Kotani, T., Watanabe, K., Chiba, K., Hosono, N., Kamatani, N., ... Ikegawa, S. (2011). A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. Nature genetics, 43(12), 1237-1240. https://doi.org/10.1038/ng.974