A genome-wide association study of hypertension-related phenotypes in a Japanese population

Yumiko Hiura, Yasuharu Tabara, Yoshihiro Kokubo, Tomonori Okamura, Tetsuro Miki, Hitonobu Tomoike, Naoharu Iwai

研究成果: Article

40 引用 (Scopus)

抄録

Background: Large-scale genome-wide association studies (GWAS) have been successful in identifying genes that contribute to common diseases and phenotypes. A GWAS of hypertension-related phenotypes in a Japanese population was conducted in the current study. Methods and Results: A total of 936 participants were recruited from the Suita Study and a GWAS with 538,732 single nucleotide polymorphisms (SNP) was performed. The phenotypes included were systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI), waist-to-hip ratio (WHR), plasma renin activity (PRA), plasma aldosterone concentration (PAC), plasma brain natriuretic peptide (BNP) concentration and alcohol consumption (AC). The SNP exceeding the genome-wide significance level were subjected to subsequent association studies using samples available from the Suita Study and Nomura Study. There is no master gene in the Japanese population that profoundly affects SBP, DBP, BMI, WHR, PRA and PAC. AC was influenced by the functional polymorphism in ALDH2, which affected BP levels in men. The BNP concentration was influenced by a polymorphism in the 3' region of the gene encoding for BNP. However, this polymorphism did not influence blood pressure (BP). Six SNP were identified to be associated with hypertension in both the Suita and Nomura studies. Conclusions: Although several candidate SNP relevant to hypertension and those influencing AC and BNP were identified, our middle-sized GWAS indicated that there is no master gene in Japanese people that profoundly affects BP-related phenotypes.

元の言語English
ページ(範囲)2353-2359
ページ数7
ジャーナルCirculation Journal
74
発行部数11
DOI
出版物ステータスPublished - 2010 11
外部発表Yes

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Genome-Wide Association Study
Brain Natriuretic Peptide
Single Nucleotide Polymorphism
Blood Pressure
Hypertension
Phenotype
Alcohol Drinking
Waist-Hip Ratio
Population
Aldosterone
Renin
Genes
Body Mass Index
Genome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

これを引用

A genome-wide association study of hypertension-related phenotypes in a Japanese population. / Hiura, Yumiko; Tabara, Yasuharu; Kokubo, Yoshihiro; Okamura, Tomonori; Miki, Tetsuro; Tomoike, Hitonobu; Iwai, Naoharu.

:: Circulation Journal, 巻 74, 番号 11, 11.2010, p. 2353-2359.

研究成果: Article

Hiura, Y, Tabara, Y, Kokubo, Y, Okamura, T, Miki, T, Tomoike, H & Iwai, N 2010, 'A genome-wide association study of hypertension-related phenotypes in a Japanese population', Circulation Journal, 巻. 74, 番号 11, pp. 2353-2359. https://doi.org/10.1253/circj.CJ-10-0353
Hiura, Yumiko ; Tabara, Yasuharu ; Kokubo, Yoshihiro ; Okamura, Tomonori ; Miki, Tetsuro ; Tomoike, Hitonobu ; Iwai, Naoharu. / A genome-wide association study of hypertension-related phenotypes in a Japanese population. :: Circulation Journal. 2010 ; 巻 74, 番号 11. pp. 2353-2359.
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AU - Miki, Tetsuro

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