A GluD Coming-Of-Age Story

Michisuke Yuzaki, A. Radu Aricescu

研究成果: Review article

23 被引用数 (Scopus)

抄録

The GluD1 and GluD2 receptors form the GluD ionotropic glutamate receptor (iGluR) subfamily. Without known endogenous ligands, they have long been referred to as ‘orphan’ and remained enigmatic functionally. Recent progress has, however, radically changed this view. Both GluD receptors are expressed in wider brain regions than originally thought. Human genetic studies and analyses of knockout mice have revealed their involvement in multiple neurodevelopmental and psychiatric disorders. The discovery of endogenous ligands, together with structural investigations, has opened the way towards a mechanistic understanding of GluD signaling at central nervous system synapses. These studies have also prompted the hypothesis that all iGluRs, and potentially other neurotransmitter receptors, rely on the cooperative binding of extracellular small-molecule and protein ligands for physiological signaling.

本文言語English
ページ(範囲)138-150
ページ数13
ジャーナルTrends in Neurosciences
40
3
DOI
出版ステータスPublished - 2017 3 1

ASJC Scopus subject areas

  • Neuroscience(all)

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