A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment

Hiroi Tomioka, Bun Yamagata, Shingo Kawasaki, Shenghong Pu, Akira Iwanami, Jinichi Hirano, Kazuyuki Nakagome, Masaru Mimura

研究成果: Article

27 引用 (Scopus)

抄録

Recent studies have indicated the potential clinical use of near infrared spectroscopy (NIRS) as a tool in assisting the diagnosis of major depressive disorder (MDD); however, it is still unclear whether NIRS signal changes during cognitive task are state- or trait-dependent, and whether NIRS could be a neural predictor of treatment response. Therefore, we conducted a longitudinal study to explore frontal haemodynamic changes following antidepressant treatment in medication-naïve MDD using 52-channel NIRS. This study included 25 medication-naïve individuals with MDD and 62 healthy controls (HC). We performed NIRS scans before and after antidepressant treatment and measured changes of [oxy-Hb] activation during a verbal fluency task (VFT) following treatment. Individuals with MDD showed significantly decreased [oxy-Hb] values during a VFT compared with HC in the bilateral frontal and temporal cortices at baseline. There were no [oxy-Hb] changes between pre- and post-antidepressant treatment time points in the MDD cohort despite significant improvement in depressive symptoms. There was a significant association between mean [oxy-Hb] values during a VFT at baseline and improvement in depressive symptoms following treatment in the bilateral inferior frontal and middle temporal gyri in MDD. These findings suggest that hypofrontality response to a VFT may represent a potential trait marker for depression rather than a state marker. Moreover, the correlation analysis indicates that the NIRS signals before the initiation of treatment may be a biological marker to predict patient's clinical response to antidepressant treatment. The present study provides further evidence to support a potential application of NIRS for the diagnosis and treatment of depression.

元の言語English
記事番号e0120828
ジャーナルPLoS One
10
発行部数3
DOI
出版物ステータスPublished - 2015 3 18

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Functional neuroimaging
antidepressants
Functional Neuroimaging
Near infrared spectroscopy
near-infrared spectroscopy
Antidepressive Agents
Near-Infrared Spectroscopy
drug therapy
Major Depressive Disorder
Depression
Therapeutics
signs and symptoms (animals and humans)
Temporal Lobe
Hemodynamics
hemodynamics
longitudinal studies
biomarkers
Frontal Lobe
cortex
Chemical activation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

これを引用

A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment. / Tomioka, Hiroi; Yamagata, Bun; Kawasaki, Shingo; Pu, Shenghong; Iwanami, Akira; Hirano, Jinichi; Nakagome, Kazuyuki; Mimura, Masaru.

:: PLoS One, 巻 10, 番号 3, e0120828, 18.03.2015.

研究成果: Article

Tomioka, Hiroi ; Yamagata, Bun ; Kawasaki, Shingo ; Pu, Shenghong ; Iwanami, Akira ; Hirano, Jinichi ; Nakagome, Kazuyuki ; Mimura, Masaru. / A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment. :: PLoS One. 2015 ; 巻 10, 番号 3.
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