A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups

Douglas Londono, Ikuyo Kou, Todd A. Johnson, Swarkar Sharma, Yoji Ogura, Tatsuhiko Tsunoda, Atsushi Takahashi, Morio Matsumoto, John A. Herring, Tsz Ping Lam, Xingyan Wang, Elisa M.S. Tam, You Qiang Song, Yan Hui Fan, Danny Chan, Kathryn S.E. Cheah, Xusheng Qiu, Hua Jiang, Dongsheng Huang, Peiqiang SuPak Sham, Kenneth M.C. Cheung, Keith D.K. Luk, Derek Gordon, Yong Qiu, Jack Cheng, Nelson Tang, Shiro Ikegawa, Carol A. Wise

研究成果: Article

37 引用 (Scopus)

抜粋

Background: Adolescent idiopathic scoliosis (AIS) is a common rotational deformity of the spine that presents in children worldwide, yet its etiology is poorly understood. Recent genome-wide association studies (GWAS) have identified a few candidate risk loci. One locus near the chromosome 10q24.31 LBX1 gene (OMIM #604255) was originally identified by a GWAS of Japanese subjects and replicated in additional Asian populations. To extend this result, and to create larger AIS cohorts for the purpose of large-scale meta-analyses in multiple ethnicities, we formed a collaborative group called the International Consortium for Scoliosis Genetics (ICSG). Methods: Here, we report the first ICSG study, a metaanalysis of the LBX1 locus in six Asian and three non- Asian cohorts. Results: We find significant evidence for association of this locus with AIS susceptibility in all nine cohorts. Results for seven cohorts containing both genders yielded P=1.22-10-43 for rs11190870, and P=2.94-10-48 for females in all nine cohorts. Comparing the regional haplotype structures for three populations, we refined the boundaries of association to a ̃25 kb block encompassing the LBX1 gene. The LBX1 protein, a homeobox transcription factor that is orthologous to the Drosophila ladybird late gene, is involved in proper migration of muscle precursor cells, specification of cardiac neural crest cells, and neuronal determination in developing neural tubes. Conclusions: Our results firmly establish the LBX1 region as the first major susceptibility locus for AIS in Asian and non-Hispanic white groups, and provide a platform for larger studies in additional ancestral groups.

元の言語English
ページ(範囲)401-406
ページ数6
ジャーナルJournal of medical genetics
51
発行部数6
DOI
出版物ステータスPublished - 2014 1 1

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

フィンガープリント A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Londono, D., Kou, I., Johnson, T. A., Sharma, S., Ogura, Y., Tsunoda, T., Takahashi, A., Matsumoto, M., Herring, J. A., Lam, T. P., Wang, X., Tam, E. M. S., Song, Y. Q., Fan, Y. H., Chan, D., Cheah, K. S. E., Qiu, X., Jiang, H., Huang, D., ... Wise, C. A. (2014). A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. Journal of medical genetics, 51(6), 401-406. https://doi.org/10.1136/jmedgenet-2013-102067