TY - JOUR
T1 - A metastatic model of human cancers using orthotopic onplantation
AU - Watanabe, M.
AU - Kubota, T.
AU - Kuo, T. H.
AU - Furukawa, T.
AU - Kitajima, M.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - We have recently developed an intact-tissue onplant method of orthotopic transplantation of human cancer xenograft, with resulting local growth, lymphatic involvement, and distant metastasis to the liver and lung, thereby reflecting the clinical situation closely. Therefore, this model represents the whole process of metastasis, consisting of local tumor growth, vascular and lymphatic invasion at the local site, flow in the vessels and lymphatic extravasation at the relevant metastatic organs, seeding the growth at the metastatic sites. The intact-tissue orthotopic-onplantation model seems to be useful to study the mechanism of metastasis for discovery of antimetastatic agents, the patient tumors and this treatment design.
AB - We have recently developed an intact-tissue onplant method of orthotopic transplantation of human cancer xenograft, with resulting local growth, lymphatic involvement, and distant metastasis to the liver and lung, thereby reflecting the clinical situation closely. Therefore, this model represents the whole process of metastasis, consisting of local tumor growth, vascular and lymphatic invasion at the local site, flow in the vessels and lymphatic extravasation at the relevant metastatic organs, seeding the growth at the metastatic sites. The intact-tissue orthotopic-onplantation model seems to be useful to study the mechanism of metastasis for discovery of antimetastatic agents, the patient tumors and this treatment design.
KW - colon cancer
KW - gastric cancer
KW - metastasis
KW - orthotopic onplantation
KW - small cell cancer
UR - http://www.scopus.com/inward/record.url?scp=0029000901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029000901&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0029000901
VL - 9
SP - 501
EP - 505
JO - Biotherapy
JF - Biotherapy
SN - 0914-2223
IS - 4
ER -