A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice

Toshiharu Furukawa, Tetsuro Kubota, Masahiko Watanabe, Tsong Hong Kuo, Hideki Nishibori, Suguru Kase, Yoshirou Saikawa, Hirokazu Tanino, Tatsuo Teramoto, Kyuya Ishibiki, Masaki Kitajima

研究成果: Article査読

25 被引用数 (Scopus)

抄録

COL-2-JCK, a human colon cancer xenograft line able to be transplanted into nude mice, was implanted in the subserosal layer of the cecum, either as cancer tissue or as a single cell suspension. When cancer tissue was used for the cecal implantation, 100% extensive local tumor growth and a high incidence of metastases to the regional lymph nodes, peritoneum, liver, and lung was observed. In contrast, when the cell suspension of this line was injected into the cecal wall, no metastases were observed, with significantly reduced local tumor growth. The use of cancer tissue maintaining the original cancer tissue structure is therefore considered imperative for allowing full expression of the biological characteristics of cancer cells. This nude mouse model using the cecal implantation of cancer tissue should thus prompt further study on the biology of human colon cancer.

本文言語English
ページ(範囲)420-423
ページ数4
ジャーナルSurgery today
23
5
DOI
出版ステータスPublished - 1993 5 1

ASJC Scopus subject areas

  • 外科

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