A microscale synthesis of a promising radiolabelled antitumor drug: Cis‐1,1‐cyclobutanedicarboxylato (2R)‐2‐methyl‐1,4‐butanediamine platinum(II), NK121

Masato Suwa, Osamu Kogawa, Hiroyoshi Nowatari, Yuko Murase, Yoshio Homma, Yutaka Hashimoto

研究成果: Article査読

3 被引用数 (Scopus)

抄録

A promising antitumor drug, cis‐1,1‐cyclobutane‐dicarboxylato (2R)‐2‐methyl‐1,4‐butanediamine platinum(II), NK121, was synthesized from radionuclides of platinum such as 193mPt, 195mPt and 191Pt which were produced by neutron irradiation of enriched 192Pt. The overall yield was 38.6% in a synthesis time of 10 hours. The radioactivities present in 8.39 mg of NK121 were 115.3 μCi as 193mPt, 29.9 μCi as 197Pt, 22.0 μCi as 195mPt, and 4.8 μCi as 191Pt at the end of synthesis. The specific activity of the NK121 was 13.7 μCi (193mPt)/mg NK121 at the end of synthesis. The radiochemical purity of NK121 was typically 99 %. HPLC analyses confirmed that NK121 was in an adequate chemical purity and suitable for animal experimentation.

本文言語English
ページ(範囲)349-354
ページ数6
ジャーナルJournal of Labelled Compounds and Radiopharmaceuticals
31
5
DOI
出版ステータスPublished - 1992 5

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 放射線学、核医学およびイメージング
  • 創薬
  • 分光学
  • 有機化学

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