A modular theory of autoimmunity

Junichiro Irie, William M. Ridgway

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

The traditional overarching concept of disease pathogenesis entails the natural history of disease, i.e. the concept that any disease is a unified entity from beginning to termination. The concept of the natural history of disease encourages researchers and clinicians alike to conceptualize all clinical signs and symptoms in a patient as manifestations of a single disease process. Our experiences in dissecting the genetic control of autoimmune diseases and autoimmune phenotypes suggest that for many autoimmune processes, an alternative conceptual framework may be more useful. We term this approach a "modular" theory of autoimmunity. "Modules" are distinct, genetically controlled clinical or pathological phenotypes which can interact to construct a disease process. Modules may interact additively, synergistically, or antagonistically in any given individual. Multiple modules can coexist and produce unique disease phenotypes. We illustrate this concept with examples from the murine autoimmune model of type one diabetes, the nonobese diabetic (NOD) mouse.

本文言語English
ページ(範囲)121-126
ページ数6
ジャーナルKeio Journal of Medicine
54
3
DOI
出版ステータスPublished - 2005 9
外部発表はい

ASJC Scopus subject areas

  • Medicine(all)

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