A nationwide multicenter study of the Cochlin tomo-protein detection test: clinical characteristics of perilymphatic fistula cases

Han Matsuda, Kei Sakamoto, Tomohiro Matsumura, Shiho Saito, Susumu Shindo, Kunihiro Fukushima, Shin ya Nishio, Ryosuke Kitoh, Osamu Shibasaki, Akinori Ito, Ryuichiro Araki, Shin ichi Usami, Mamoru Suzuki, Kaoru Ogawa, Tomonori Hasegawa, Yoshiaki Hagiwara, Yasuhiro Kase, Tetsuo Ikezono

研究成果: Article

5 引用 (Scopus)

抄録

Objective: To investigate the positive rate for the Cochlin tomo-protein (CTP: an inner ear-specific protein) detection test among patients with inner ear-related clinical manifestations and evaluate the clinical characteristics of definite perilymphatic fistula (PLF). Methods: We have performed an ELISA-based CTP detection test using middle ear lavage (MEL) samples from 497 cases of suspected PLF enrolled from 70 clinical centers nationwide between 2014 and 2015. In addition to the CTP-positive rate, audio-vestibular symptoms were compared between CTP-positive and -negative cases. Results: 8–50% of patients in category 1 (trauma, middle and inner ear disease cases), and about 20% of those in categories 2, 3 and 4 (external origin antecedent events, internal origin antecedent events, and without antecedent event, respectively) were positive for CTP. In category 1 cases, the earlier tested samples showed a higher CTP-positive rate, whereas no differences were observed in categories 2, 3 or 4. The characteristic clinical features in the earlier tested cases were nystagmus and fistula sign in CTP test-positive cases in category 1, and streaming water-like tinnitus in those in categories 2, 3 and 4. Conclusion: The present study clarified that CTP detection test-positive patients exist at considerable rates among patients with inner ear-related manifestations.

元の言語English
ページ(範囲)1-7
ページ数7
ジャーナルActa Oto-Laryngologica
DOI
出版物ステータスAccepted/In press - 2017 3 31

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Cytidine Triphosphate
Multicenter Studies
Fistula
Proteins
Inner Ear
Middle Ear
Labyrinth Diseases
Tinnitus
Therapeutic Irrigation
Enzyme-Linked Immunosorbent Assay
Water
Wounds and Injuries

ASJC Scopus subject areas

  • Otorhinolaryngology

これを引用

A nationwide multicenter study of the Cochlin tomo-protein detection test : clinical characteristics of perilymphatic fistula cases. / Matsuda, Han; Sakamoto, Kei; Matsumura, Tomohiro; Saito, Shiho; Shindo, Susumu; Fukushima, Kunihiro; Nishio, Shin ya; Kitoh, Ryosuke; Shibasaki, Osamu; Ito, Akinori; Araki, Ryuichiro; Usami, Shin ichi; Suzuki, Mamoru; Ogawa, Kaoru; Hasegawa, Tomonori; Hagiwara, Yoshiaki; Kase, Yasuhiro; Ikezono, Tetsuo.

:: Acta Oto-Laryngologica, 31.03.2017, p. 1-7.

研究成果: Article

Matsuda, H, Sakamoto, K, Matsumura, T, Saito, S, Shindo, S, Fukushima, K, Nishio, SY, Kitoh, R, Shibasaki, O, Ito, A, Araki, R, Usami, SI, Suzuki, M, Ogawa, K, Hasegawa, T, Hagiwara, Y, Kase, Y & Ikezono, T 2017, 'A nationwide multicenter study of the Cochlin tomo-protein detection test: clinical characteristics of perilymphatic fistula cases', Acta Oto-Laryngologica, pp. 1-7. https://doi.org/10.1080/00016489.2017.1300940
Matsuda, Han ; Sakamoto, Kei ; Matsumura, Tomohiro ; Saito, Shiho ; Shindo, Susumu ; Fukushima, Kunihiro ; Nishio, Shin ya ; Kitoh, Ryosuke ; Shibasaki, Osamu ; Ito, Akinori ; Araki, Ryuichiro ; Usami, Shin ichi ; Suzuki, Mamoru ; Ogawa, Kaoru ; Hasegawa, Tomonori ; Hagiwara, Yoshiaki ; Kase, Yasuhiro ; Ikezono, Tetsuo. / A nationwide multicenter study of the Cochlin tomo-protein detection test : clinical characteristics of perilymphatic fistula cases. :: Acta Oto-Laryngologica. 2017 ; pp. 1-7.
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abstract = "Objective: To investigate the positive rate for the Cochlin tomo-protein (CTP: an inner ear-specific protein) detection test among patients with inner ear-related clinical manifestations and evaluate the clinical characteristics of definite perilymphatic fistula (PLF). Methods: We have performed an ELISA-based CTP detection test using middle ear lavage (MEL) samples from 497 cases of suspected PLF enrolled from 70 clinical centers nationwide between 2014 and 2015. In addition to the CTP-positive rate, audio-vestibular symptoms were compared between CTP-positive and -negative cases. Results: 8–50{\%} of patients in category 1 (trauma, middle and inner ear disease cases), and about 20{\%} of those in categories 2, 3 and 4 (external origin antecedent events, internal origin antecedent events, and without antecedent event, respectively) were positive for CTP. In category 1 cases, the earlier tested samples showed a higher CTP-positive rate, whereas no differences were observed in categories 2, 3 or 4. The characteristic clinical features in the earlier tested cases were nystagmus and fistula sign in CTP test-positive cases in category 1, and streaming water-like tinnitus in those in categories 2, 3 and 4. Conclusion: The present study clarified that CTP detection test-positive patients exist at considerable rates among patients with inner ear-related manifestations.",
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author = "Han Matsuda and Kei Sakamoto and Tomohiro Matsumura and Shiho Saito and Susumu Shindo and Kunihiro Fukushima and Nishio, {Shin ya} and Ryosuke Kitoh and Osamu Shibasaki and Akinori Ito and Ryuichiro Araki and Usami, {Shin ichi} and Mamoru Suzuki and Kaoru Ogawa and Tomonori Hasegawa and Yoshiaki Hagiwara and Yasuhiro Kase and Tetsuo Ikezono",
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T1 - A nationwide multicenter study of the Cochlin tomo-protein detection test

T2 - clinical characteristics of perilymphatic fistula cases

AU - Matsuda, Han

AU - Sakamoto, Kei

AU - Matsumura, Tomohiro

AU - Saito, Shiho

AU - Shindo, Susumu

AU - Fukushima, Kunihiro

AU - Nishio, Shin ya

AU - Kitoh, Ryosuke

AU - Shibasaki, Osamu

AU - Ito, Akinori

AU - Araki, Ryuichiro

AU - Usami, Shin ichi

AU - Suzuki, Mamoru

AU - Ogawa, Kaoru

AU - Hasegawa, Tomonori

AU - Hagiwara, Yoshiaki

AU - Kase, Yasuhiro

AU - Ikezono, Tetsuo

PY - 2017/3/31

Y1 - 2017/3/31

N2 - Objective: To investigate the positive rate for the Cochlin tomo-protein (CTP: an inner ear-specific protein) detection test among patients with inner ear-related clinical manifestations and evaluate the clinical characteristics of definite perilymphatic fistula (PLF). Methods: We have performed an ELISA-based CTP detection test using middle ear lavage (MEL) samples from 497 cases of suspected PLF enrolled from 70 clinical centers nationwide between 2014 and 2015. In addition to the CTP-positive rate, audio-vestibular symptoms were compared between CTP-positive and -negative cases. Results: 8–50% of patients in category 1 (trauma, middle and inner ear disease cases), and about 20% of those in categories 2, 3 and 4 (external origin antecedent events, internal origin antecedent events, and without antecedent event, respectively) were positive for CTP. In category 1 cases, the earlier tested samples showed a higher CTP-positive rate, whereas no differences were observed in categories 2, 3 or 4. The characteristic clinical features in the earlier tested cases were nystagmus and fistula sign in CTP test-positive cases in category 1, and streaming water-like tinnitus in those in categories 2, 3 and 4. Conclusion: The present study clarified that CTP detection test-positive patients exist at considerable rates among patients with inner ear-related manifestations.

AB - Objective: To investigate the positive rate for the Cochlin tomo-protein (CTP: an inner ear-specific protein) detection test among patients with inner ear-related clinical manifestations and evaluate the clinical characteristics of definite perilymphatic fistula (PLF). Methods: We have performed an ELISA-based CTP detection test using middle ear lavage (MEL) samples from 497 cases of suspected PLF enrolled from 70 clinical centers nationwide between 2014 and 2015. In addition to the CTP-positive rate, audio-vestibular symptoms were compared between CTP-positive and -negative cases. Results: 8–50% of patients in category 1 (trauma, middle and inner ear disease cases), and about 20% of those in categories 2, 3 and 4 (external origin antecedent events, internal origin antecedent events, and without antecedent event, respectively) were positive for CTP. In category 1 cases, the earlier tested samples showed a higher CTP-positive rate, whereas no differences were observed in categories 2, 3 or 4. The characteristic clinical features in the earlier tested cases were nystagmus and fistula sign in CTP test-positive cases in category 1, and streaming water-like tinnitus in those in categories 2, 3 and 4. Conclusion: The present study clarified that CTP detection test-positive patients exist at considerable rates among patients with inner ear-related manifestations.

KW - biomarker

KW - Cochlin isoform

KW - ELISA

KW - hearing loss

KW - perilymph

KW - Perilymphatic fistula

KW - tinnitus

KW - vertigo

KW - vestibular symptom

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