A neurospheroid cultured on the tip of a flexible microelectrode for cortical microstimulation

Keisuke Okita, Midori Kato-Negishi, Koji Sato, Hiroaki Onoe, Shoji Takeuchi

研究成果: Conference contribution

抄録

This paper describes a flexible microelectrode combined with a neuronal spheroid (neurospheroid) cultured on the electrode tip. Prior works have found that neurons of a neurospheroid can extend their axons to form synaptic connections with neurons inside living neuronal tissues, that could enable such tissues to be stimulated via transplanted neurons (i.e., instead of through the insertion of invasive probes). Here we present a parylene-based flexible microelectrode that enables activation of neurospheroid cultured on the electrode. Experiments revealed that our probe successfully activated neurons within neurospheroids, resulting in neurite extension onto the electrode. These results mark an important step toward achieving minimally-invasive cortical microstimulation via neurospheroid-based probing systems.

本文言語English
ホスト出版物のタイトルProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
出版社Chemical and Biological Microsystems Society
ページ1024-1026
ページ数3
ISBN(印刷版)9780979806452
出版ステータスPublished - 2012 1 1
外部発表はい
イベント16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
継続期間: 2012 10 282012 11 1

出版物シリーズ

名前Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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