A new approach to antiplatelet therapy: Inhibitor of GPIb/V/IX-vWF interaction

Yasuo Ikeda, Makoto Handa, Mitsuru Murata, Shinya Goto

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Evidence has been presented that the interaction between von Willebrand factor (vWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis. A monoclonal antibody against the A1 domain of vWF has been shown to inhibit thrombus formation in the animal model of arterial thrombosis. Based upon these findings, a new approach to treating arterial thrombosis has been proposed by intervening in the interaction between vWF and platelet.

本文言語English
ページ(範囲)44-52
ページ数9
ジャーナルHaemostasis
30
SUPPL. 3
DOI
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 血液学

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