A new, convenient cell-based screening method for small-molecule glycolytic inhibitors

Mitsuhiro Kitagawa; Mayuko Misawa; Seiichiro Ogawa; Etsu Tashiro; Masaya Imoto

doi:10.1271/bbb.100693

A new, convenient cell-based screening method for small-molecule glycolytic inhibitors

Mitsuhiro Kitagawa, Mayuko Misawa, Seiichiro Ogawa, Etsu Tashiro, Masaya Imoto

生命情報学科

研究成果: Article › 査読

5 被引用数 (Scopus)

抄録

To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.

本文言語	English
ページ（範囲）	367-369
ページ数	3
ジャーナル	Bioscience, Biotechnology and Biochemistry
巻	75
号	2
DOI	https://doi.org/10.1271/bbb.100693
出版ステータス	Published - 2011 3 7

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

文献へのアクセス

10.1271/bbb.100693

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引用スタイル

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