A new leishmanicidal saponin from Brunfelsia grandiflora

Hiroyuki Fuchino, Setsuko Sekita, Kanami Mori, Nobuo Kawahara, Motoyoshi Satake, Fumiyuki Kiuchi

研究成果: Article査読

21 被引用数 (Scopus)

抄録

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O- β-D-glucopyranosyl 22 α-methoxyfurost-3β,26-diol 3-O-β-D-xylopyranosyl(1→3)-{β-D-glucopyranosyl(1→2)} -β-D-glucopyranosyl(1→4)-β-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

本文言語English
ページ(範囲)93-96
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
56
1
DOI
出版ステータスPublished - 2008 1
外部発表はい

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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