抄録
Hooded Gunn rats which have low-activity of 4-nitrophenol uridine diphosphateglucuronosyltransferase (GT) and defect in bilirubin GT were crossed with albino LA Wistar rats with a defect in androsterone GT. From F2 and F3 progeny were selected Gunn-LA Wistar rats which have defective bilirubin and androsterone GTs and low-active 4-nitrophenol GT. These rats had either hooded or albino coat color. In order to establish a uniform genetic background, albino male Gunn-LA Wistar rats were crossed with heterozygous albino female Gunn-LA Wistar rats in terms of bilirubin GT. The offsprings were all albino and were classified to Gunn-LA Wistar rats and heterozygous Gunn-LA Wistar rats by assaying their hepatic GT activities or by the appearance of jaundice. The linkage relationships between GT and coat color genes are discussed.
本文言語 | English |
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ページ(範囲) | 305-309 |
ページ数 | 5 |
ジャーナル | Journal of Pharmacobio-Dynamics |
巻 | 12 |
号 | 5 |
DOI | |
出版ステータス | Published - 1989 12月 |
ASJC Scopus subject areas
- 薬理学