A novel blood glucose monitoring system was developed by applying an SOS/ISFET (silicon on sapphire/ion-sensitive field-effect transistor) biosensor to an SEF (suction effusion fluid). The effusion rate of the SEF was 11.9 ± 3.7 μlh-1 cm-2 and the measurement was made every 7.5 min. Glucose concentrations measured using SEF showed a good correlation with those measured by using serum with a slight delay of about 10 min. The blood glucose monitoring system was successfully applied to a non-invasive transcutaneous blood glucose monitoring on human 75 g oral glucose tolerance test. This result shows it will enable realization of a portable blood glucose monitoring device and the system will become very useful in medical treatment.
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