A novel combined chemotherapy using TS-1 and low-dose cisplatin against liver metastasis of gastric cancer

Yoshiro Saikawa, Toshio Kanai, Yukio Kawano, Yoshihide Otani, Tetsuro Kubota, Masaki Kitajima

研究成果: Article査読

4 被引用数 (Scopus)

抄録

We used a novel combination chemotherapy of TS-1 and low-dose cisplatin (CDDP) with 4 gastric cancer patients with liver metastases (one far advanced and 3 recurrent patients). TS-1 was administered at 80 mg-120 mg/body/day, twice daily for 3 weeks followed by a 2-week interval as one cycle, and CDDP was administered at 6 mg/m2/day div, for 5 days followed by a 2-day interval (1 cycle for an inpatient) or at 6 mg/m2/day div, at 5 times for 2-3 weeks (1 cycle for an outpatient). Efficacy and toxicity were evaluated after 3-6 cycles of the regimen, as long as the patients tolerated the regimen without severe side effects. This regimen resulted in 1 complete response, 2 partial responses and 1 progressive disease, showing a 75% efficacy rate. One patient experienced grade 2 nausea from this regimen, which was ameliorated by means of prolonging the interval of CDDP-administration. Thus, the regimen is useful to maintain patients' quality of life without severe adverse effects, and has a high efficacy in gastric cancer patients with liver metastases.

本文言語English
ページ(範囲)1241-1245
ページ数5
ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
29
7
出版ステータスPublished - 2002 7

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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