A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells

Katsuhiko Tabuchi, Shingo Yoshikawa, Yoshihiro Yuasa, Kazunobu Sawamoto, Hideyuki Okano

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We have isolated a novel Drosophila paired-like homeobox gene, DPHD-1. The homeodomain of DPHD-1 showed 85% amino-acid identity with that of the C. elegans Unc-4 protein. Whole-mount in situ hybridization of embryos and third-instar larvae revealed that the DPHD-1 mRNA is specifically localized in subsets of postmitotic neurons in the central nervous system (CNS) and in the developing epidermis with a segmentally repeated pattern. Double staining with a posterior compartment marker, an anti-Engrailed antibody, showed that DPHD-1 expressing neurons in the CNS were present in the posterior compartment, whereas DPHD-1 expression in the epidermis was restricted to the anterior compartment in each segment. This temporal and spatial expression pattern suggests that DPHD-1 may play a role in determining the distinct cell types in each segment.

本文言語English
ページ(範囲)49-52
ページ数4
ジャーナルNeuroscience Letters
257
1
DOI
出版ステータスPublished - 1998 11 20
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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