A novel monocyclic dienediyne system: Synthesis and mode of aromatization

Kazunobu Toshima, Koji Yanagawa, Kazumi Ohta, Takaaki Kano, Masaya Nakata

研究成果: Article査読

15 被引用数 (Scopus)

抄録

The novel monocyclic dienediyne 2, which is a simplified analogue of the neocarzinostatin chromophore (1), was synthesized from D-xylitol via conversion of the keto-aldehyde 13 into the highly strained 10-membered ring compound 14 by a simple intramolecular aldol condensation as the key step. The mode of cycloaromatization of 2 by a thiol addition, reminiscent of the chemistry of 1, was also demonstrated.

本文言語English
ページ(範囲)1573-1576
ページ数4
ジャーナルTetrahedron Letters
35
10
DOI
出版ステータスPublished - 1994 3 7

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

フィンガープリント 「A novel monocyclic dienediyne system: Synthesis and mode of aromatization」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル