A paradigm shift in rheumatoid arthritis over the past decade

研究成果: Review article査読

13 被引用数 (Scopus)

抄録

Recent advances have improved our understanding of the pathogenesis of rheumatoid arthritis (RA), and the development of new therapeutics, including biological agents, have thus made it possible to strive for remission as a primary goal. Biological agents targeting a specific molecule have powerful functional capabilities, and the introduction of biological therapies has brought about revolutionary progress in RA management, culminating in a paradigm shift. There is clear evidence that a delay in treatment initiation and poor control of disease activity are associated with joint damage progression, so treatment should be started immediately after the diagnosis of RA and adapted according to disease activity as assessed by validated composite measures. In this review, we will summarize the changes in the classification and remission criteria and describe the clinical efficacies of biological agents in RA. We also discuss new promising therapies and propose future perspectives in the rheumatology field.

本文言語English
ページ(範囲)1895-1903
ページ数9
ジャーナルInternal Medicine
53
17
DOI
出版ステータスPublished - 2014

ASJC Scopus subject areas

  • Internal Medicine

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