A peptide motif recognizing a polymer stereoregularity

Takeshi Serizawa; Toshiki Sawada; Hisao Matsuno; Teruhiko Matsubara; Toshinori Sato

doi:10.1021/ja054402o

A peptide motif recognizing a polymer stereoregularity

Takeshi Serizawa, Toshiki Sawada, Hisao Matsuno, Teruhiko Matsubara, Toshinori Sato

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研究成果: Article › 査読

81 被引用数 (Scopus)

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A combinatorial phage display method was applied to films composed of a stereoregular polymer of methacrylates. The phage clones with selective affinity for isotactic (it) poly(methyl methacrylate) (PMMA) were isolated. Greater amounts of the phage clones bound to it-PMMA, compared to other stereoregular PMMAs. The phage expressing ELWRPTR most strongly bound to the polymer, and the selectivity was also the best. The peptide motif essential for the specific interaction with the stereoregular polymer was revealed.

本文言語	English
ページ（範囲）	13780-13781
ページ数	2
ジャーナル	Journal of the American Chemical Society
巻	127
号	40
DOI	https://doi.org/10.1021/ja054402o
出版ステータス	Published - 2005 10月 12

ASJC Scopus subject areas

触媒
化学 (全般)
生化学
コロイド化学および表面化学

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10.1021/ja054402o

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author = "Takeshi Serizawa and Toshiki Sawada and Hisao Matsuno and Teruhiko Matsubara and Toshinori Sato",

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AU - Serizawa, Takeshi

AU - Sawada, Toshiki

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AU - Matsubara, Teruhiko

AU - Sato, Toshinori

PY - 2005/10/12

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AB - A combinatorial phage display method was applied to films composed of a stereoregular polymer of methacrylates. The phage clones with selective affinity for isotactic (it) poly(methyl methacrylate) (PMMA) were isolated. Greater amounts of the phage clones bound to it-PMMA, compared to other stereoregular PMMAs. The phage expressing ELWRPTR most strongly bound to the polymer, and the selectivity was also the best. The peptide motif essential for the specific interaction with the stereoregular polymer was revealed.

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A peptide motif recognizing a polymer stereoregularity

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