A pharmacokinetic analysis program (multi) for microcomputer

Kiyoshi Yamaoka, Yusuke Tanigawara, Terumichi Nakagawa, Toyozo Uno

研究成果: Article査読

2630 被引用数 (Scopus)

抄録

A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions or MULTI are demonstrated for time courses of ampicillin and oxacillin in man.

本文言語English
ページ(範囲)879-885
ページ数7
ジャーナルJournal of Pharmacobio-Dynamics
4
11
DOI
出版ステータスPublished - 1981
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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