A possible defensive mechanism in the basal region of gastric mucosa and the healing of erosions

Masashi Yoshida, Go Wakabayashi, Hideki Ishikawa, Kaori Kameyama, Motohide Shimazu, Minoru Tanabe, Shigeyuki Kawachi, Koichiro Kumai, Tetsuro Kubota, Yoshihide Otani, Yoshiro Saikawa, Katsuko Sano, Masaki Kitajima

研究成果: Article

9 引用 (Scopus)

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A possible defensive mechanism in the basal region of the gastric mucosa was hypothesized in the present study. In vivo microscopy was performed to observe the basal region after thermal injury to the back skin of rats. A donor of nitric oxide, 3-morpholinosydnonimine hydrochloride (SIN-1), or a serine protease inhibitor, camostat mesilate, was administered. Anti-vascular endothelial growth factor (VEGF) neutralizing antibody was administered 5 hours after thermal injury (anti-VEGF group). Post-capillary venules could be observed in the basal region of the gastric mucosa (PV-BGM). The PV-BGM was dilated 5 hours after thermal injury, and it was reduced by the administration of SIN-1 or pre-treatment with camostat mesilate. In the control group, the erosions did not reach the basal region of the gastric mucosa. Most of the erosions healed within 72 hours. Delayed healing was observed in the anti-VEGF group. In this group, exudation and congestion in the basal region were observed at 24 hours, and ulcer formation was observed at 72 hours after thermal injury. It is thus hypothesized that blood flow of the PV-BGM increases when superficial mucosal circulation is disturbed. The PV-BGM can contribute to defensive mechanisms in the basal region of gastric mucosa. The abnormal healing process may disturb the defensive mechanism at the base of the gastric mucosa, thereby resulting in ulcer formation.

元の言語English
ページ(範囲)301-312
ページ数12
ジャーナルClinical Hemorheology and Microcirculation
29
発行部数3-4
出版物ステータスPublished - 2003 12 1

ASJC Scopus subject areas

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

フィンガープリント A possible defensive mechanism in the basal region of gastric mucosa and the healing of erosions' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Yoshida, M., Wakabayashi, G., Ishikawa, H., Kameyama, K., Shimazu, M., Tanabe, M., Kawachi, S., Kumai, K., Kubota, T., Otani, Y., Saikawa, Y., Sano, K., & Kitajima, M. (2003). A possible defensive mechanism in the basal region of gastric mucosa and the healing of erosions. Clinical Hemorheology and Microcirculation, 29(3-4), 301-312.