A Possible Mechanism of Immunotherapy for Patients With Recurrent Spontaneous Abortions

TOSHITAKA SUGI, TSUNEHISA MAKINO, TETSUO MARUYAMA, WOO KYOON KIM, RIHACHI IIZUKA

研究成果: Article査読

19 被引用数 (Scopus)

抄録

ABSTRACT: The mechanism of the beneficial effect of immunotherapy for human reproductive wastage remains to be elucidated. Induction of blocking antibodies such as anti‐HLA class II antibodies and anti‐idiotypic antibodies was investigated as the mechanism of specific immunosuppression in pregnancy. We reported the changes in the mixed lymphocyte reaction (MLR), T‐cell subsets, and generation of anti‐idiotypic antibodies after immunotherapy compared to before immunotherapy. MLR was significantly (P < 0.001) inhibited after the immunization. The mean inhibition rate was 50.2%, suggesting that MLR blocking antibodies were induced by immunotherapy. Binding of autoantibodies to alloactivated maternal lymphoblasts against the paternal lymphocytes was detected in postimmunization cases in two‐color flow‐cytometric experiments. This suggests that anti‐idiotypic antibodies were induced by the immunotherapy. The percentage of cytotoxic T‐cells was significantly decreased (P < 0.05) and the percentage of suppressor T‐cells was significantly increased (P < 0.01) after the immunotherapy, suggesting that a cell‐mediated immune response was induced by the immunotherapy. 1991 Munksgaard

本文言語English
ページ(範囲)185-189
ページ数5
ジャーナルAmerican Journal of Reproductive Immunology
25
4
DOI
出版ステータスPublished - 1991 5

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 生殖医学
  • 産婦人科学

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