A practical approach for the chemical synthesis of 2′-deoxyguanosine-C8 adducts with mutagenic/carcinogenic amino- or nitro-arenes

Takeji Takamura-Enya, Satoko Ishikawa, Masataka Mochizuki, Keiji Wakabayashi

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Synthetic methods for the preparation of 2′-deoxyguanosine-C8 (dG-C8) adducts with several mutagenic and carcinogenic amino- or nitro-arenes were developed using the palladium-mediated cross-coupling reaction of protected 8-amino-dG with bromoarenes in around 80% yields, followed by conventional deprotection procedures. This approach can be applied to preparation of a variety of authentic dG-C8 adducts with amino or nitro-arenes.

本文言語English
ページ(範囲)5969-5973
ページ数5
ジャーナルTetrahedron Letters
44
32
DOI
出版ステータスPublished - 2003 8月 4

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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