A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome

Masaru Mimura, Fumiko Hoeft, Motoichiro Kato, Nobuhisa Kobayashi, Kristen Sheau, Judith Piggot, Debra Mills, Albert Galaburda, Julie R. Korenberg, Ursula Bellugi, Allan L. Reiss

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Individuals with Williams syndrome (WS) demonstrate an abnormally positive social bias. However, the neural substrates of this hypersociability, i. e., positive attribution bias and increased drive toward social interaction, have not fully been elucidated. Methods: We performed an event-related functional magnetic resonance imaging study while individuals with WS and typically developing controls (TD) matched positive and negative emotional faces. WS compared to TD showed reduced right amygdala activation during presentation of negative faces, as in the previous literature. In addition, WS showed a unique pattern of right orbitofrontal cortex activation. While TD showed medial orbitofrontal cortex activation in response to positive, and lateral orbitofrontal cortex activation to negative, WS showed the opposite pattern. In light of the general notion of a medial/lateral gradient of reward/punishment processing in the orbitofrontal cortex, these findings provide an additional biological explanation for, or correlate of positive attribution bias and hypersociability in WS.

本文言語English
ページ(範囲)93-98
ページ数6
ジャーナルJournal of Neurodevelopmental Disorders
2
2
DOI
出版ステータスPublished - 2010 6
外部発表はい

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 病理学および法医学
  • 臨床神経学
  • 認知神経科学

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