A randomized controlled study of rG.CSF in patients with neutropenia after induction therapy for acute myelogenous leukemia. (rG.CSF Clinical Study Group)

H. Nakajima, Y. Ikeda, K. Hirashima, K. Toyama, M. Okuma, H. Saito, R. Ohno, M. Tomonaga, S. Asano

研究成果: Article査読

8 被引用数 (Scopus)

抄録

A randomized treated/non-treated study of rG.CSF (5 micrograms/kg/d, d.i.v.) in patients with acute myelogenous leukemia was conducted to assess its efficacy on fever (> or = 38 degrees C) or documented infection after induction therapy. Of 95 patients enrolled, 46 patients were evaluable for safety and 43 for efficacy in the treated group of 47 patients while 37 of 48 patients were eligible for data analysis in the untreated group. Mare patients showed a recovery in the blood neutrophil count (to > 1,000/microliters) during rG.CSF treatment (14 days) than in the non-treated group (p = 0.039) while the number of febrile patients and duration of fever did not significantly differ between the two groups. The treatment with rG.CSF enabled an early recovery in neutrophil count in the patients with neutropenia and overt signs of infection after induction therapy, but there was no hastened allevistion of symptoms of infection in these patients.

本文言語English
ページ(範囲)597-605
ページ数9
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
36
6
出版ステータスPublished - 1995 6
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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