A rapid synthesis of [82Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [82Br]‐ 2‐deoxy‐2‐bromo‐D‐glucose using D‐glucal as precursor

Yoshio Homma, Yuko Murase, Michiko Ishii, Kazue Sonehara

研究成果: Article査読

4 被引用数 (Scopus)

抄録

A new rapid synthesis of [82Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [82Br]‐2‐deoxy‐2‐bromo‐D‐glucose is described. Reaction of 82Br2 with D‐glucal in CHCl3, followed by treatment with 1 N HCl gave [82Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [82Br]‐2‐deoxy‐2‐bromo‐D‐glucose in the yield of 61.1 % and 27.7 %, respectively. The synthesis time was 20 min. The radiochemical purity of [82Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [82Br]‐2‐deoxy‐2‐bromo‐D‐glucose was greater than 95 %. The radiochemical yield of [82Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [82 Br]‐2‐deoxy‐2‐bromo‐D‐glucose was 14.3 % and 31.6 %, respectively. D‐Glucal was shown to be a useful precursor to allow rapid production of usable amounts of glucose analogs such as [75Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [75Br]‐2‐deoxy‐2‐bromo‐D‐glucose.

本文言語English
ページ(範囲)791-797
ページ数7
ジャーナルJournal of Labelled Compounds and Radiopharmaceuticals
23
7
DOI
出版ステータスPublished - 1986 7

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 放射線学、核医学およびイメージング
  • 創薬
  • 分光学
  • 有機化学

フィンガープリント

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