抄録
A new rapid synthesis of [82Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [82Br]‐2‐deoxy‐2‐bromo‐D‐glucose is described. Reaction of 82Br2 with D‐glucal in CHCl3, followed by treatment with 1 N HCl gave [82Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [82Br]‐2‐deoxy‐2‐bromo‐D‐glucose in the yield of 61.1 % and 27.7 %, respectively. The synthesis time was 20 min. The radiochemical purity of [82Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [82Br]‐2‐deoxy‐2‐bromo‐D‐glucose was greater than 95 %. The radiochemical yield of [82Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [82 Br]‐2‐deoxy‐2‐bromo‐D‐glucose was 14.3 % and 31.6 %, respectively. D‐Glucal was shown to be a useful precursor to allow rapid production of usable amounts of glucose analogs such as [75Br]‐2‐deoxy‐2‐bromo‐D‐mannose and [75Br]‐2‐deoxy‐2‐bromo‐D‐glucose.
本文言語 | English |
---|---|
ページ(範囲) | 791-797 |
ページ数 | 7 |
ジャーナル | Journal of Labelled Compounds and Radiopharmaceuticals |
巻 | 23 |
号 | 7 |
DOI | |
出版ステータス | Published - 1986 7月 |
ASJC Scopus subject areas
- 分析化学
- 生化学
- 放射線学、核医学およびイメージング
- 創薬
- 分光学
- 有機化学