A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

Yuichi Hashimoto, Takako Niikura, Hirohisa Tajima, Takashi Yasukawa, Haruka Sudo, Yuko Ito, Yoshiko Kita, Masaoki Kawasumi, Keisuke Kouyama, Manabu Doyu, Gen Sobue, Takashi Koide, Shoji Tsuji, Jochen Lang, Kiyoshi Kurokawa, Ikuo Nishimoto

研究成果: Article査読

449 被引用数 (Scopus)

抄録

Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN. This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.

本文言語English
ページ(範囲)6336-6341
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
98
11
DOI
出版ステータスPublished - 2001 5月 22

ASJC Scopus subject areas

  • 一般

フィンガープリント

「A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル