TY - JOUR
T1 - A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine
AU - Koide, Yuichiro
AU - Kawaguchi, Mitsuyasu
AU - Urano, Yasuteru
AU - Hanaoka, Kenjiro
AU - Komatsu, Toru
AU - Abo, Masahiro
AU - Terai, Takuya
AU - Nagano, Tetsuo
PY - 2012/2/27
Y1 - 2012/2/27
N2 - We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo
AB - We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo
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U2 - 10.1039/c2cc18011a
DO - 10.1039/c2cc18011a
M3 - Article
C2 - 22344329
AN - SCOPUS:84857776863
VL - 48
SP - 3091
EP - 3093
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 25
ER -