TY - JOUR
T1 - A rheostat for immune responses
T2 - The unique properties of PD-1 and their advantages for clinical application
AU - Okazaki, Taku
AU - Chikuma, Shunsuke
AU - Iwai, Yoshiko
AU - Fagarasan, Sidonia
AU - Honjo, Tasuku
N1 - Funding Information:
We thank N. Minato and colleagues at Kyoto University for scientific expertise. Supported by Core Research for Evolutional Science and Technology Program of the Japan Science and Technology Agency (T.O.), Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology (23790534 and 25460363 to S.C.), the Senri Life Science Foundation (S.C.) and Grants-in-Aid for Scientific Research in Priority Areas and RIKEN’s President Discretionary Fund (S.F.).
PY - 2013/12
Y1 - 2013/12
N2 - PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastating fatal autoimmune disease of mice deficient in the immunomodulatory receptor CTLA-4, suggest that immunoregulation by PD-1 is rather antigen specific and is mainly cell intrinsic. Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment.
AB - PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastating fatal autoimmune disease of mice deficient in the immunomodulatory receptor CTLA-4, suggest that immunoregulation by PD-1 is rather antigen specific and is mainly cell intrinsic. Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=84887862839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887862839&partnerID=8YFLogxK
U2 - 10.1038/ni.2762
DO - 10.1038/ni.2762
M3 - Review article
C2 - 24240160
AN - SCOPUS:84887862839
SN - 1529-2908
VL - 14
SP - 1212
EP - 1218
JO - Nature Immunology
JF - Nature Immunology
IS - 12
ER -
