A simple behavioral test for locomotor function after brain injury in mice

Masanao Tabuse, Masae Yaguchi, Shigeki Ohta, Takeshi Kawase, Masahiro Toda

研究成果: Article査読

6 被引用数 (Scopus)

抄録

To establish a simple and reliable test for assessing locomotor function in mice with brain injury, we developed a new method, the rotarod slip test, in which the number of slips of the paralytic hind limb from a rotarod is counted. Brain injuries of different severity were created in adult C57BL/6 mice, by inflicting 1-point, 2-point and 4-point cryo-injuries. These mice were subjected to the rotarod slip test, the accelerating rotarod test and the elevated body swing test (EBST). Histological analyses were performed to assess the severity of the brain damage. Significant and consistent correlations between test scores and severity were observed for the rotarod slip test and the EBST. Only the rotarod slip test detected the mild hindlimb paresis in the acute and sub-acute phase after injury. Our results suggest that the rotarod slip test is the most sensitive and reliable method for assessing locomotor function after brain damage in mice.

本文言語English
ページ(範囲)1412-1416
ページ数5
ジャーナルJournal of Clinical Neuroscience
17
11
DOI
出版ステータスPublished - 2010 11月

ASJC Scopus subject areas

  • 外科
  • 神経学
  • 臨床神経学
  • 生理学(医学)

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