A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

J. L. Espinoza, A. Takami, M. Onizuka, T. Kawase, H. Sao, H. Akiyama, K. Miyamura, S. Okamoto, M. Inoue, S. Ohtake, T. Fukuda, Y. Morishima, Y. Kodera, S. Nakao

研究成果: Article査読

20 被引用数 (Scopus)

抄録

IL-17 has an important role in the host defense against extracellular pathogens and the pathophysiology of autoimmune diseases. This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of a total 510 recipients with hematologic malignancies and their unrelated donors on the clinical outcomes in HLA-matched myeloablative (discovery study) and nonmyeloablative (validation study) BMT through the Japan Marrow Donor Program (JMDP). In the discovery study, the presence of a 197A genotype in the recipient resulted in a higher incidence of grades II-IV acute GVHD (hazard ratio (HR), 1.87; 95% confidence interval (CI), 1.23-2.85; P=.004). The donor IL-17A genotype did not significantly influence the transplant outcomes. The validation study showed a trend toward an association of the recipient 197A genotype with an increased risk of grades III-IV acute GVHD (HR, 5.84; 95% CI, 0.75-45.72; P=.09), as well as a significantly increased risk for chronic GVHD (HR, 3.86; 95% CI, 1.29-11.59; P=.02). These results suggest an association of the 197A genotype in the recipient side with the development of acute GVHD.

本文言語English
ページ(範囲)1455-1463
ページ数9
ジャーナルBone Marrow Transplantation
46
11
DOI
出版ステータスPublished - 2011 11

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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