A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

J. L. Espinoza, A. Takami, M. Onizuka, T. Kawase, H. Sao, H. Akiyama, K. Miyamura, Shinichiro Okamoto, M. Inoue, S. Ohtake, T. Fukuda, Y. Morishima, Y. Kodera, S. Nakao

研究成果: Article

20 引用 (Scopus)

抄録

IL-17 has an important role in the host defense against extracellular pathogens and the pathophysiology of autoimmune diseases. This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of a total 510 recipients with hematologic malignancies and their unrelated donors on the clinical outcomes in HLA-matched myeloablative (discovery study) and nonmyeloablative (validation study) BMT through the Japan Marrow Donor Program (JMDP). In the discovery study, the presence of a 197A genotype in the recipient resulted in a higher incidence of grades II-IV acute GVHD (hazard ratio (HR), 1.87; 95% confidence interval (CI), 1.23-2.85; P=.004). The donor IL-17A genotype did not significantly influence the transplant outcomes. The validation study showed a trend toward an association of the recipient 197A genotype with an increased risk of grades III-IV acute GVHD (HR, 5.84; 95% CI, 0.75-45.72; P=.09), as well as a significantly increased risk for chronic GVHD (HR, 3.86; 95% CI, 1.29-11.59; P=.02). These results suggest an association of the 197A genotype in the recipient side with the development of acute GVHD.

元の言語English
ページ(範囲)1455-1463
ページ数9
ジャーナルBone Marrow Transplantation
46
発行部数11
DOI
出版物ステータスPublished - 2011 11

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Interleukin-17
Single Nucleotide Polymorphism
Genotype
Validation Studies
Confidence Intervals
Genes
Unrelated Donors
Hematologic Neoplasms
Autoimmune Diseases
Japan
Bone Marrow
Tissue Donors
Transplants
Incidence

ASJC Scopus subject areas

  • Hematology
  • Transplantation

これを引用

A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT. / Espinoza, J. L.; Takami, A.; Onizuka, M.; Kawase, T.; Sao, H.; Akiyama, H.; Miyamura, K.; Okamoto, Shinichiro; Inoue, M.; Ohtake, S.; Fukuda, T.; Morishima, Y.; Kodera, Y.; Nakao, S.

:: Bone Marrow Transplantation, 巻 46, 番号 11, 11.2011, p. 1455-1463.

研究成果: Article

Espinoza, JL, Takami, A, Onizuka, M, Kawase, T, Sao, H, Akiyama, H, Miyamura, K, Okamoto, S, Inoue, M, Ohtake, S, Fukuda, T, Morishima, Y, Kodera, Y & Nakao, S 2011, 'A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT', Bone Marrow Transplantation, 巻. 46, 番号 11, pp. 1455-1463. https://doi.org/10.1038/bmt.2010.325
Espinoza, J. L. ; Takami, A. ; Onizuka, M. ; Kawase, T. ; Sao, H. ; Akiyama, H. ; Miyamura, K. ; Okamoto, Shinichiro ; Inoue, M. ; Ohtake, S. ; Fukuda, T. ; Morishima, Y. ; Kodera, Y. ; Nakao, S. / A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT. :: Bone Marrow Transplantation. 2011 ; 巻 46, 番号 11. pp. 1455-1463.
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abstract = "IL-17 has an important role in the host defense against extracellular pathogens and the pathophysiology of autoimmune diseases. This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of a total 510 recipients with hematologic malignancies and their unrelated donors on the clinical outcomes in HLA-matched myeloablative (discovery study) and nonmyeloablative (validation study) BMT through the Japan Marrow Donor Program (JMDP). In the discovery study, the presence of a 197A genotype in the recipient resulted in a higher incidence of grades II-IV acute GVHD (hazard ratio (HR), 1.87; 95{\%} confidence interval (CI), 1.23-2.85; P=.004). The donor IL-17A genotype did not significantly influence the transplant outcomes. The validation study showed a trend toward an association of the recipient 197A genotype with an increased risk of grades III-IV acute GVHD (HR, 5.84; 95{\%} CI, 0.75-45.72; P=.09), as well as a significantly increased risk for chronic GVHD (HR, 3.86; 95{\%} CI, 1.29-11.59; P=.02). These results suggest an association of the 197A genotype in the recipient side with the development of acute GVHD.",
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AU - Espinoza, J. L.

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AU - Onizuka, M.

AU - Kawase, T.

AU - Sao, H.

AU - Akiyama, H.

AU - Miyamura, K.

AU - Okamoto, Shinichiro

AU - Inoue, M.

AU - Ohtake, S.

AU - Fukuda, T.

AU - Morishima, Y.

AU - Kodera, Y.

AU - Nakao, S.

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