A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration

Ryosuke Oguro, Kei Kamide, Tomohiro Katsuya, Hiroshi Akasaka, Ken Sugimoto, Ada Congrains, Yasumichi Arai, Nobuyoshi Hirose, Shigeyuki Saitoh, Mitsuru Ohishi, Tetsuji Miura, Hiromi Rakugi

研究成果: Article

19 引用 (Scopus)

抄録

Background: Single nucleotide polymorphisms (SNPs) of the adenosine deaminase, RNA-specific (ADAR) gene were reported to be associated with human longevity. There are possibilities that ADAR is associated with major risk factors of atherosclerotic cardiovascular diseases (CVD), such as hypertension, diabetes, dyslipidemia, and obesity. Objective: To investigate the association between SNPs of the ADAR gene and clinical data associated with major risk factors of atherosclerotic CVD. Subjects: A total of 1504 general population residents (586 males and 918 females) of two towns, Tanno-cho and Sobestu-cho, in Hokkaido, Japan. Methods: Clinical data associated with risk factors of atherosclerotic CVD were collected from these study subjects. DNA from peripheral blood and written informed consent were obtained. Three single nucleotide polymorphisms of . ADARB1 and . ADARB2, which were previously reported to be associated with longevity, were genotyped employing the TaqMan PCR method. The associations between SNPs in . ADARB1 and . ADARB2 and clinical parameters related to risk factors of atherosclerosis were analyzed. Results: On uni- and multivariate analyses, rs2805533 in . ADARB2 was significantly associated with the abdominal circumference, body mass index, serum triglyceride level, and serum adiponectin level. The subjects with the AA genotype of rs2805533 had a greater abdominal circumference, higher body mass index, higher triglyceride level, and lower adiponectin level than those with AG and GG genotypes. Conclusion: The SNP in . ADARB2 related to longevity is associated with metabolic disorders. This finding suggests that genetic factors modulate human longevity via the regulation of metabolic factors such as abdominal obesity and lipid profiles.

元の言語English
ページ(範囲)183-187
ページ数5
ジャーナルExperimental Gerontology
47
発行部数2
DOI
出版物ステータスPublished - 2012 2

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Adenosine Deaminase
Adiponectin
Polymorphism
Single Nucleotide Polymorphism
Triglycerides
Nucleotides
Genes
RNA
Serum
Cardiovascular Diseases
Body Mass Index
Genotype
Abdominal Obesity
Medical problems
Dyslipidemias
Human engineering
Informed Consent
Atherosclerosis
Japan
Blood

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

これを引用

A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration. / Oguro, Ryosuke; Kamide, Kei; Katsuya, Tomohiro; Akasaka, Hiroshi; Sugimoto, Ken; Congrains, Ada; Arai, Yasumichi; Hirose, Nobuyoshi; Saitoh, Shigeyuki; Ohishi, Mitsuru; Miura, Tetsuji; Rakugi, Hiromi.

:: Experimental Gerontology, 巻 47, 番号 2, 02.2012, p. 183-187.

研究成果: Article

Oguro, Ryosuke ; Kamide, Kei ; Katsuya, Tomohiro ; Akasaka, Hiroshi ; Sugimoto, Ken ; Congrains, Ada ; Arai, Yasumichi ; Hirose, Nobuyoshi ; Saitoh, Shigeyuki ; Ohishi, Mitsuru ; Miura, Tetsuji ; Rakugi, Hiromi. / A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration. :: Experimental Gerontology. 2012 ; 巻 47, 番号 2. pp. 183-187.
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title = "A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration",
abstract = "Background: Single nucleotide polymorphisms (SNPs) of the adenosine deaminase, RNA-specific (ADAR) gene were reported to be associated with human longevity. There are possibilities that ADAR is associated with major risk factors of atherosclerotic cardiovascular diseases (CVD), such as hypertension, diabetes, dyslipidemia, and obesity. Objective: To investigate the association between SNPs of the ADAR gene and clinical data associated with major risk factors of atherosclerotic CVD. Subjects: A total of 1504 general population residents (586 males and 918 females) of two towns, Tanno-cho and Sobestu-cho, in Hokkaido, Japan. Methods: Clinical data associated with risk factors of atherosclerotic CVD were collected from these study subjects. DNA from peripheral blood and written informed consent were obtained. Three single nucleotide polymorphisms of . ADARB1 and . ADARB2, which were previously reported to be associated with longevity, were genotyped employing the TaqMan PCR method. The associations between SNPs in . ADARB1 and . ADARB2 and clinical parameters related to risk factors of atherosclerosis were analyzed. Results: On uni- and multivariate analyses, rs2805533 in . ADARB2 was significantly associated with the abdominal circumference, body mass index, serum triglyceride level, and serum adiponectin level. The subjects with the AA genotype of rs2805533 had a greater abdominal circumference, higher body mass index, higher triglyceride level, and lower adiponectin level than those with AG and GG genotypes. Conclusion: The SNP in . ADARB2 related to longevity is associated with metabolic disorders. This finding suggests that genetic factors modulate human longevity via the regulation of metabolic factors such as abdominal obesity and lipid profiles.",
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author = "Ryosuke Oguro and Kei Kamide and Tomohiro Katsuya and Hiroshi Akasaka and Ken Sugimoto and Ada Congrains and Yasumichi Arai and Nobuyoshi Hirose and Shigeyuki Saitoh and Mitsuru Ohishi and Tetsuji Miura and Hiromi Rakugi",
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TY - JOUR

T1 - A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration

AU - Oguro, Ryosuke

AU - Kamide, Kei

AU - Katsuya, Tomohiro

AU - Akasaka, Hiroshi

AU - Sugimoto, Ken

AU - Congrains, Ada

AU - Arai, Yasumichi

AU - Hirose, Nobuyoshi

AU - Saitoh, Shigeyuki

AU - Ohishi, Mitsuru

AU - Miura, Tetsuji

AU - Rakugi, Hiromi

PY - 2012/2

Y1 - 2012/2

N2 - Background: Single nucleotide polymorphisms (SNPs) of the adenosine deaminase, RNA-specific (ADAR) gene were reported to be associated with human longevity. There are possibilities that ADAR is associated with major risk factors of atherosclerotic cardiovascular diseases (CVD), such as hypertension, diabetes, dyslipidemia, and obesity. Objective: To investigate the association between SNPs of the ADAR gene and clinical data associated with major risk factors of atherosclerotic CVD. Subjects: A total of 1504 general population residents (586 males and 918 females) of two towns, Tanno-cho and Sobestu-cho, in Hokkaido, Japan. Methods: Clinical data associated with risk factors of atherosclerotic CVD were collected from these study subjects. DNA from peripheral blood and written informed consent were obtained. Three single nucleotide polymorphisms of . ADARB1 and . ADARB2, which were previously reported to be associated with longevity, were genotyped employing the TaqMan PCR method. The associations between SNPs in . ADARB1 and . ADARB2 and clinical parameters related to risk factors of atherosclerosis were analyzed. Results: On uni- and multivariate analyses, rs2805533 in . ADARB2 was significantly associated with the abdominal circumference, body mass index, serum triglyceride level, and serum adiponectin level. The subjects with the AA genotype of rs2805533 had a greater abdominal circumference, higher body mass index, higher triglyceride level, and lower adiponectin level than those with AG and GG genotypes. Conclusion: The SNP in . ADARB2 related to longevity is associated with metabolic disorders. This finding suggests that genetic factors modulate human longevity via the regulation of metabolic factors such as abdominal obesity and lipid profiles.

AB - Background: Single nucleotide polymorphisms (SNPs) of the adenosine deaminase, RNA-specific (ADAR) gene were reported to be associated with human longevity. There are possibilities that ADAR is associated with major risk factors of atherosclerotic cardiovascular diseases (CVD), such as hypertension, diabetes, dyslipidemia, and obesity. Objective: To investigate the association between SNPs of the ADAR gene and clinical data associated with major risk factors of atherosclerotic CVD. Subjects: A total of 1504 general population residents (586 males and 918 females) of two towns, Tanno-cho and Sobestu-cho, in Hokkaido, Japan. Methods: Clinical data associated with risk factors of atherosclerotic CVD were collected from these study subjects. DNA from peripheral blood and written informed consent were obtained. Three single nucleotide polymorphisms of . ADARB1 and . ADARB2, which were previously reported to be associated with longevity, were genotyped employing the TaqMan PCR method. The associations between SNPs in . ADARB1 and . ADARB2 and clinical parameters related to risk factors of atherosclerosis were analyzed. Results: On uni- and multivariate analyses, rs2805533 in . ADARB2 was significantly associated with the abdominal circumference, body mass index, serum triglyceride level, and serum adiponectin level. The subjects with the AA genotype of rs2805533 had a greater abdominal circumference, higher body mass index, higher triglyceride level, and lower adiponectin level than those with AG and GG genotypes. Conclusion: The SNP in . ADARB2 related to longevity is associated with metabolic disorders. This finding suggests that genetic factors modulate human longevity via the regulation of metabolic factors such as abdominal obesity and lipid profiles.

KW - Adenosine deaminase

KW - Adiponectin

KW - Adiposity

KW - Longevity

KW - Metabolic disorders

KW - RNA-specific gene polymorphism

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