TY - JOUR
T1 - A survey of the clinical course and management of Japanese patients deficient in natural anticoagulants
AU - Yokoyama, Kenji
AU - Kojima, Tetsuhito
AU - Sakata, Yoichi
AU - Kawasaki, Tomio
AU - Tsuji, Hajime
AU - Miyata, Toshiyuki
AU - Okamoto, Shinichiro
AU - Murata, Mitsuru
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: supported in part by Grant-in-Aid for Blood Coagulation Abnormalities from Ministry Health, Labor and Welfare of Japan.
PY - 2012/9
Y1 - 2012/9
N2 - Few data are available on the clinical course of Japanese patients deficient in natural anticoagulants (antithrombin (AT), protein C, and protein S). We conducted a nationwide survey to reveal the clinical course of these patients. Questionnaires were sent to 321 council members of the Japanese Society on Thrombosis and Hemostasis, Japanese Society for Vascular Surgery, and Japanese Society of Phlebology. A total of 103 responses were obtained and data of 183 patients were collected. Of 183 patients, 142 (78%) experienced at least one episode of venous thromboembolism (VTE). The first VTE occurred before the age of 40 years in 71 patients (45%). Venous thromboembolism recurred in 15 (39%) patients with AT deficiency and 19 (18%) patients with other deficiencies. These findings suggest that half of the first episodes of VTE in patients deficient in natural anticoagulants occur before middle age and the risk of VTE recurrence is high in patients with AT deficiency.
AB - Few data are available on the clinical course of Japanese patients deficient in natural anticoagulants (antithrombin (AT), protein C, and protein S). We conducted a nationwide survey to reveal the clinical course of these patients. Questionnaires were sent to 321 council members of the Japanese Society on Thrombosis and Hemostasis, Japanese Society for Vascular Surgery, and Japanese Society of Phlebology. A total of 103 responses were obtained and data of 183 patients were collected. Of 183 patients, 142 (78%) experienced at least one episode of venous thromboembolism (VTE). The first VTE occurred before the age of 40 years in 71 patients (45%). Venous thromboembolism recurred in 15 (39%) patients with AT deficiency and 19 (18%) patients with other deficiencies. These findings suggest that half of the first episodes of VTE in patients deficient in natural anticoagulants occur before middle age and the risk of VTE recurrence is high in patients with AT deficiency.
KW - anticoagulants
KW - thrombophilia
KW - venous thromboembolism
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U2 - 10.1177/1076029611435839
DO - 10.1177/1076029611435839
M3 - Article
C2 - 22311628
AN - SCOPUS:84871775673
VL - 18
SP - 506
EP - 513
JO - Clinical and Applied Thrombosis/Hemostasis
JF - Clinical and Applied Thrombosis/Hemostasis
SN - 1076-0296
IS - 5
ER -